T176
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T176
Fluka
4-Hydroxytamoxifen
(E) and (Z) isomers (50:50)
| Synonym: | 4-OHT, trans-4-Hydroxytamoxifen, (Z)-4-(1-[4-(Dimethylaminoethoxy)phenyl]-2-phenyl-1-butenyl)phenol |
| CAS Number: | 68047-06-3 |
| Linear Formula: | C26H29NO2 |
| Molecular Weight: | 387.51 |
| MDL number: | MFCD00278780 |
| PubChem Substance ID: | 24899989 |
Description
| Biochem/physiol Actions | Metabolite of the chemotherapeutic drug tamoxifen, exhibiting more potent estrogen agonist/antagonist activity than the parent drug. Also active as intra-membranous inhibitor of lipid peroxidation. |
Properties
| form | powder |
| color | white |
| solubility | ethanol: 20 mg/mL |
| Gene Information | human ... ESR1(2099), ESR2(2100), ESRRG(2104), IL6(3569) |
| rat ... Ar(24208), Esr1(24890), Esr2(25149) | |
| storage temp. | 2-8°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-63 |
| Safety Statements | 22-23-36 |
| WGK Germany | 3 |
| RTECS | SL1210000 |
References
| reference | Kupfer, D., et al. Cancer Res. 54, 3140, (1994) |
| Custodio, J.B.A., et al. Biochem. Pharmacol. 47, 1989, (1994) | |
| Manns, J.E., et al. Anal. Proc. 30, 161, (1993) | |
| Murphy, C.S., et al. Mol. Pharmacol. 38, 737, (1991) |
